The Effect of Hemodialysis on Activity of Erythrocyte Immune Function and T Lymphocyte Subsets in Patients with Uremia

Objective To investigate the change of erythrocyte immune function and T lymphocyte subsets in patients with uremia and the effect of hemodialysis on them. Methods Flow cytometry and immune adherence rosette method were used to measure the activity of RBC-CR1and the changes of T lymphocyte subsets in 23 uremic patients without hemodialysis, 22 uremic patients before and after sigle hemodialysis and 21 healthy subjects as the control group. Results The activity of RBC-CR1, the number of T lymphocyte subsets significantly changed in patients with uremia, and hemodialysis could partially improve this condition. There was obvious correlation between erythrocyte immune function and T lymphocyte subsets. Serum creatinine was positively relative to the value of RBC-C 3b RR(P0.01), and negatively relative to CD 4 +/CD 8 + ratio(P0.01). Conclusion Erythrocyte immune adherent function and T lymphocyte subsets obviously declined in the uremic patients,and their changes were related to the damage of renal function. Erythrocyte immunity may regulate the activity of some immune cells including T lymphocyte subsets. Hemodialysis can partially improve erythrocyte immune insuffciency and cell immune dysfunction.