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The Effect of Glutathione and Tetrandrine on Mitochondrial Complex I and ROS of Brain in rats with Parkinson Disease

Zhou Hou-guang

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Abstract

Objective To observe the effects of glutathione(GSH) and tetrandrine(Tet) on nigral and striatum antioxidation system and mitochondrial complex I function in Parkinson disease(PD) model rat. Methods The PD rats model were established through stereotoxic microinjection of 6-OHDA.The model rats were randomly divided into 4 groups:model group, GSH group, GSH+Tet group,L-dopa group and normal group. In each group drug treatment was given for 50 days.The activity of mitochondrial complexI in nigra and ROS in striatum were assayed after treatment. Results GSH+Tet group could increasely decrease the contents of ROS in striatum. GSH+Tet could produce some protective effect on mitochondrial respiration chain. Conclusion GSH+Tet group could decrease the nigral and striatum oxidative stress in PD model rats,and produce some protective effect on mitochondria respiration chain.

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What this paper is about

Objective To observe the effects of glutathione(GSH) and tetrandrine(Tet) on nigral and striatum antioxidation system and mitochondrial complex I function in Parkinson disease(PD) model rat. Methods The PD rats model were established through stereotoxic microinjection of 6-OHDA.The model rats were randomly divided into 4 groups:model group, GSH group, GSH+Tet group,L-dopa group and normal group. In each group drug treatment was given for 50 days.The activity of mitochondrial complexI in nigra and ROS in striatum were assayed after treatment. Results GSH+Tet group could increasely decrease the contents of ROS in striatum. GSH+Tet could produce some protective effect on mitochondrial respiration chain. Conclusion GSH+Tet group could decrease the nigral and striatum oxidative stress in PD model rats,and produce some protective effect on mitochondria respiration chain.

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Available abstract

Objective To observe the effects of glutathione(GSH) and tetrandrine(Tet) on nigral and striatum antioxidation system and mitochondrial complex I function in Parkinson disease(PD) model rat. Methods The PD rats model were established through stereotoxic microinjection of 6-OHDA.The model rats were randomly divided into 4 groups:model group, GSH group, GSH+Tet group,L-dopa group and normal group. In each group drug treatment was given for 50 days.The activity of mitochondrial complexI in nigra and ROS in striatum were assayed after treatment. Results GSH+Tet group could increasely decrease the contents of ROS in striatum. GSH+Tet could produce some protective effect on mitochondrial respiration chain. Conclusion GSH+Tet group could decrease the nigral and striatum oxidative stress in PD model rats,and produce some protective effect on mitochondria respiration chain.

Key concepts: Glutathione, Tetrandrine, Striatum, Parkinson's disease, Oxidative stress, Mitochondrion, Chemistry, Internal medicine

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The Effect of Glutathione and Tetrandrine on Mitochondrial Complex I and ROS of Brain in rats with Parkinson Disease — Research Paper | ScholarLens