2004•Chinese Journal of Clinical NeurosciencesRequires access

Experimental Study on Antagonism of Glutathione to Levodopa's Cytotoxicity

Jian Lu

Abstract

Aim:To observe the antagonism of glutathione to levodopa's cytotoxicity.Methods:The rats were divided into four groups:negative contrast group,positive contrast group,treatment group and normal group.All rats behaviors were tested before and after giving medicine.The activity of GSH-Px,content of MDA,ROS and Mitochondrionase complex Ⅰof nigra were assayed.Results:Glutathione could decrease the nigral oxidative stress and descending of mitochondrial respiration chain complex Ⅰ of PD model rats that levodopa caused.Conclusion:GSH could antagonize partly levodopa's cytotoxicity,and exert some cyto-protection effect on model rats for PD.

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Key concepts: Glutathione, Levodopa, Cytotoxicity, Antagonism, Oxidative stress, Pharmacology, Chemistry, Parkinson's disease