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Effects of Atorvastatin on hs-CRP and IL-6 in patients with acute coronary syndrome

Ge Xiaoli

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Abstract

Objective To investigate the effects of Atorvastatin on hs-CRP and IL-6 in acute coronary syndrome.Methods 86 patients with ACS were divided randomly into statin group(n=46) and control group(n=40).Statin group received Atorvastatin(20mg/d) on the basis of conventional treatment of control group.The levers of AST,ALT,CK,hs-CRP and IL-6 were detected before and after for 1 treatment months.Results There were no significant differences in the levels of AST,ALT,and CK between the two groups before and after treatment(P0.05).After treatment the levels of hs-CRP and IL-6 in control group were significantly lower than that before treatment(P0.05).After treatment the levels of hs-CRP and IL-6 in statin group were significantly lower than that of control and before treatment(P0.01and P0.001).Conclusion Atorvastatin can decrease hs-CRP and IL-6 levels in patients with ACS,which contributes to suppression of inflammation response.

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What this paper is about

Objective To investigate the effects of Atorvastatin on hs-CRP and IL-6 in acute coronary syndrome.Methods 86 patients with ACS were divided randomly into statin group(n=46) and control group(n=40).Statin group received Atorvastatin(20mg/d) on the basis of conventional treatment of control group.The levers of AST,ALT,CK,hs-CRP and IL-6 were detected before and after for 1 treatment months.Results There were no significant differences in the levels of AST,ALT,and CK between the two groups before and after treatment(P0.05).After treatment the levels of hs-CRP and IL-6 in control group were significantly lower than that before treatment(P0.05).After treatment the levels of hs-CRP and IL-6 in statin group were significantly lower than that of control and before treatment(P0.01and P0.001).Conclusion Atorvastatin can decrease hs-CRP and IL-6 levels in patients with ACS,which contributes to suppression of inflammation response.

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Available abstract

Objective To investigate the effects of Atorvastatin on hs-CRP and IL-6 in acute coronary syndrome.Methods 86 patients with ACS were divided randomly into statin group(n=46) and control group(n=40).Statin group received Atorvastatin(20mg/d) on the basis of conventional treatment of control group.The levers of AST,ALT,CK,hs-CRP and IL-6 were detected before and after for 1 treatment months.Results There were no significant differences in the levels of AST,ALT,and CK between the two groups before and after treatment(P0.05).After treatment the levels of hs-CRP and IL-6 in control group were significantly lower than that before treatment(P0.05).After treatment the levels of hs-CRP and IL-6 in statin group were significantly lower than that of control and before treatment(P0.01and P0.001).Conclusion Atorvastatin can decrease hs-CRP and IL-6 levels in patients with ACS,which contributes to suppression of inflammation response.

Key concepts: Atorvastatin, Medicine, Acute coronary syndrome, Internal medicine, Gastroenterology, Statin, C-reactive protein, Inflammation

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Effects of Atorvastatin on hs-CRP and IL-6 in patients with acute coronary syndrome — Research Paper | ScholarLens