The Relationship of Paraoxonase-1Q/R192 Gene Polymorphism with Atherosclerotic Cerebral Infarction in Ningxia Han Population

Objective To explore the relationship between the PONI Q192R gene polymorphism and atherosclerotic cerebral infarction among Han population in Ningxia.Methods A total of 74 ACI patients and 65 control subjects were recruited in this study.PON1 Q/R192 gene polymorphisms were monitored using poly- merise chainreaction-restriction fragment length polymorphism(PCR-RFLP).Results The distribution of the PON1Q/R polymorphism between ACI patients and control groups was QQ genotype:9.46%(7/74), 21.54%(14/65);QR genotype:48.65%(36/74),44.62%(29/65);RR genotype:41.89%(31/74), 33.84%(22/65).There were significant difference for QQ and RR genotypes of Q192R polymorphism between ACI group and in control subjects(P0.05).There was no significant difference for QR genotype(P 0.05).In the above two groups allele frequency was Q:0.338,0.438;R:0.662,0.562.There were significant difference between ACI patients and control groups.Conclusion The present study suggests that there is signifi- cant association between PON1 Q/R polymorphism and ACI among Hart population in Ningxia.