The study on the association between interleukin-6572C/G gene polymorphism and cerebral infarction.

Objective To investigate whether IL-6-572C/G polymorphism is associated with atherosclerotic cerebral infarction(ACI) in a Han population in Hunan Province.Methods The distributions of allele and genotype frequencies of 572C/G polymorphism of IL-6 gene were examined in 199 patients with ACI and 196 healthy controls using Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results There was significant difference in genotype of 572C/G polymorphism between ACI patients and controls(X2=5.120,P0.05).There was significant difference in frequencies of allele of 572C/G polymorphism between ACI patients and controls(frequencies of C and G allele,ACI group :0.741,0.259 VS control group: 0.816、0.184)(X2=5.491,P0.05).Logistic regression analysis showed that polymorphism GG genotype of the IL-6 gene-572C/G polymorphism was associated with ACI(OR=3.216,95 %CI:1.145-6.732).Conclusions Homozygous GG genotype of IL-6 gene-572C/G polymorphism may be one of the predisposing genes of ACI in a Han population in Hunan province.