The Comparison of Clinical Therapeutic Effects On Primary Hypertension between Perindopril and Captopril

Objective To assess the clinial therapeutic effects of perindopril and captopril on primary hypertension. Methods Sixty-one subjects ( 34 male, 27 female ) were enrolled in the study. There were thirty-one subjects in perindopril group, and thirty in captopril group, in which perindopril and captopril were administered at the dosage of 4 mg/d ( qd ) and 75mg/d ( tid ) persubject. All subjects in both perindopril group and captopril group were treated for 30 days, and then were assessed statistically. Results There were gigniicant differences between the two groups (P0.05 ). Systolic blood pressure ( SBP ) and diastolic blood pressure (DBP) of perindopril group decreased more significantly (P0.01,P0.05 ). There were no clear changes in lab test such as blood urea nitrogen ( BUN ), creatinine ( Cre ), K+ and Na+. Conclusion It is suggested that perindopril should be the first choice when angiotensin converting enzyme inhibitor (ACEI) is taken into account for the therapy of primary hypertension.