Analgesic Effects of Parecoxib on Lower Limb Surgery

Objective To investigate the analgesic effects of parecoxib on lower limb surgery.Methods forty-five patients,ASA Ⅰor Ⅱ,undergoing lower limb surgery under general anesthesia were randomly divided into three groups:group A(40mg parecoxib before anesthesia induction ),B(40mg parecoxib on closure of the wound) and C(control group). All patients received patient-controlled subcutaneous analgesia (PCSA,containing fentanyl 2.0mg diluted to 100ml) at the end of the surgery. Visual analog score (VAS) was recorded to evaluate post-operative pain at the time of analepsia (T1),and 4 h(T2),24 h(T3) and 36 h(T4) after the surgery. PCSA button press times,total fentanyl usage and the incidence of dizziness,nausea and vomiting were also recorded. Results The VAS score at T1-T3 were significantly lower in group A and group B than those in group C (P0.05),and the VAS score at T1,T2 were significantly lower in group A than those in group B(P0.05). PCSA button press times and total fentanyl usage 24 hours after surgery and the incidence of post-operative nausea and vomiting were lower in group A and group B than those in group C(P0.05)Conclusion Parecoxib can provide good analgesia on low limb surgery and it has a preemptive analgesic effect.