Comparative study of ziprasidone and risperidone in the treatment of schizophrenia

Objective To explore the efficacy and side effects of ziprasidone for treating patients with schizophrenia.Methods A total of 60 patients with schizophrenia were randomly divided into ziprasidone group (30 cases) and risperidone group(30 cases) for the treatment of 8 weeks.Indicators included Positive and Negative Symptom Scale(PANSS) and Clinical Global Impression scale(CGI) for efficacy,Treatment Emergent Symptom Scale(TESS) and the laboratory for side effects. Results The effective rates of ziprasidone group and risperidone group were 86.7% and 90.0% after 8-week treatment,and there was no significant difference between two groups.At the end of treatment,PANSS scores of both groups significantly reduced,no significant difference was found between two groups,however,ziprasidone had better effect on negative symptoms than risperidone. The patients treated with ziprasidone showed fewer side effects including weight gain,Extra Pyramidal Symptoms(EPS) and menses change than the patients with risperidone.Conclusion Ziprasidone is effective in the treatment of schizophrenia,specifically improving negative symptoms. Ziprasidone has fewer side effects compared with risperidone.