Ziprasidone and risperidone in the treatment of schizophrenia:A comparative study

Objective: To compare the efficacy and safety of ziprasidone and resperidone in the treatment of schizophrenia.Methods: Sixty-four patients with schizophrenia were randomly assigned as two groups treated with ziprasidone or risperidone for 8 weeks.The positive and negative symptom scale(PANSS) and treatment emergent symptoms scale(TESS)were used t o evaluate the efficacy and adverse effects before and at the end of 2,4,8 weeks of treatment.Results:The total effective rates of ziprasidone and risperidone were 81.2% and 84.3% respectively after 8-week treatments.There was no significant difference between two groups(P0.05).The patients treated with ziprasidone showed fewer side effects including weight gain,Extra Pyramidal Symptoms(EPS) and menses change than the patients with risperidone.Conclusion: Ziprasidone is effective in the treatment of schizophrenia,specifically improving negative symptoms.Ziprasidone has fewer side effects compared with risperidone.