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The Content of NO in Brain of Rats with Focal Cerebral Ischemia Reperfusion Injury

Jianxiong Li

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Abstract

Objective To study the content of nitric oxide (NO) in different brain tissue in rats with focal cerebral ischemia reperfusion injury. Methods Modified intravascular embolism method was employed to make focal ischemia in rats. Nitrite reduction method was used to detect the content of NO in brain. Results ①Compared with the normal group,the content of NO had remarkably increased in bilateral cortex and hippocampus after cerebral ischemia reperfusion(P0.05);②The content of NO in ischemia side was no more than opposite side. Conclusion Cerebral ischemia reperfusion in one side can induce bilateral damage in brain.

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Objective To study the content of nitric oxide (NO) in different brain tissue in rats with focal cerebral ischemia reperfusion injury. Methods Modified intravascular embolism method was employed to make focal ischemia in rats. Nitrite reduction method was used to detect the content of NO in brain. Results ①Compared with the normal group,the content of NO had remarkably increased in bilateral cortex and hippocampus after cerebral ischemia reperfusion(P0.05);②The content of NO in ischemia side was no more than opposite side. Conclusion Cerebral ischemia reperfusion in one side can induce bilateral damage in brain.

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Available abstract

Objective To study the content of nitric oxide (NO) in different brain tissue in rats with focal cerebral ischemia reperfusion injury. Methods Modified intravascular embolism method was employed to make focal ischemia in rats. Nitrite reduction method was used to detect the content of NO in brain. Results ①Compared with the normal group,the content of NO had remarkably increased in bilateral cortex and hippocampus after cerebral ischemia reperfusion(P0.05);②The content of NO in ischemia side was no more than opposite side. Conclusion Cerebral ischemia reperfusion in one side can induce bilateral damage in brain.

Key concepts: Ischemia, Nitric oxide, Hippocampus, Medicine, Reperfusion injury, Cerebral cortex, Anesthesia, Brain tissue

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