2005•Unpublished venueRequires access

The Expression of nNOS in Brain of Rats with Focal Cerebral Ischemia Reperfusion Injury

Hou Jian

Abstract

Objective To study the expression of neuron nitric oxide synthase(nNOS) in different brain tissue in rats with focal cerebral ischemia reperfusion injury.Methods Modified intravascular embolism method was employed to make focal ischemia in rats.Immunohistochemical method was used to detect the expression of nNOS in brain.Results ①Compared with the normal group,the expression of nNOS had remarkably enhanced after cerebral ischemia reperfusion(P0.05);②The nNOS expression in ischemia side was more obvious than opposite side in cortex,CA_1 and CA3(P0.05).Conclusion Cerebral ischemia reperfusion injury in one side can lead to damage in another side,but the former is more serious.

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Key concepts: Ischemia, Immunohistochemistry, Medicine, Nitric oxide synthase, Nitric oxide, Cerebral embolism, Embolism, Cerebral cortex