THE Expression of MRP and LRP in Gastric Carcinoma

Objective To study the expression and clinical significance of MRP(multidrug resistance associated protein) and LRP(lung resistance protein) in gastric carcinoma.Methods Immunohistochemistry was used to examine the MRP and LRP expression in 90 cases of gastric carcinoma and 30 cases of normal stomach tissues.Results The positive expression rates of MRP and LRP in the 90 cases of gastric carcinoma was 92.2% and 93.3% respectively and was all significantly higher than those in normal stomach tissues( P 0.05).The positive expression rates in high moderated differented adenocarcinoma were significantly higher than those in poorly differented adenocarcinoma and mucoid carcinoma.The expression of them had no correlation to different depth of invasion or lymph nodes metastasis.Conclusion MRP and LRP are all highly expressed in gastric carcinoma and play important roles in the primary multidrug resistence(MDR) of gastric carcinoma.