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1999•Chinese Journal of Current Advances in General SurgeryRequires access

THE EXPRESSION OF mdr-l,MRP AND LRP GENES IN GASTRIC CARCINOMA AND THEIR CLINICAL SIGNIFICANCE

Zhongmin Liu, Shou Nan-ha, Xihong Jiang

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Abstract

Objective: To explore the expression of mdr-1,multidrug resistance associated protein(MRP)and lung resistance protein(LRP) genes in human gastric cancer and their clinical significance. Methods: The mdr-1 mRNA was assayed by RT-PCR,the MRP and LRP were detected by flow cytometry. Results : The positive rate of mdr-l mRNA is 44.496(12/27), and the mean MRP and LRP expression rate is 39.1% and 29.9%, respectively. The mdr-1 mRNA, MRP or LRP expression is independent of patient histologic type, nodal involvement, and TNM stage.The mdr-1 mRNA expression in patients with serosa invasion was 30.0%(6/20), much lower than that without serosa invasion (85. 7%). Conclusion: The multidrug resistance cells are present in primary gastric carcinomas prior to chemotherapy and analysis of mdr-l gene, MRP, LRP may have guiding significance in the treatment of gastric carcinoma.

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Objective: To explore the expression of mdr-1,multidrug resistance associated protein(MRP)and lung resistance protein(LRP) genes in human gastric cancer and their clinical significance. Methods: The mdr-1 mRNA was assayed by RT-PCR,the MRP and LRP were detected by flow cytometry. Results : The positive rate of mdr-l mRNA is 44.496(12/27), and the mean MRP and LRP expression rate is 39.1% and 29.9%, respectively. The mdr-1 mRNA, MRP or LRP expression is independent of patient histologic type, nodal involvement, and TNM stage.The mdr-1 mRNA expression in patients with serosa invasion was 30.0%(6/20), much lower than that without serosa invasion (85. 7%). Conclusion: The multidrug resistance cells are present in primary gastric carcinomas prior to chemotherapy and analysis of mdr-l gene, MRP, LRP may have guiding significance in the treatment of gastric carcinoma.

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Available abstract

Objective: To explore the expression of mdr-1,multidrug resistance associated protein(MRP)and lung resistance protein(LRP) genes in human gastric cancer and their clinical significance. Methods: The mdr-1 mRNA was assayed by RT-PCR,the MRP and LRP were detected by flow cytometry. Results : The positive rate of mdr-l mRNA is 44.496(12/27), and the mean MRP and LRP expression rate is 39.1% and 29.9%, respectively. The mdr-1 mRNA, MRP or LRP expression is independent of patient histologic type, nodal involvement, and TNM stage.The mdr-1 mRNA expression in patients with serosa invasion was 30.0%(6/20), much lower than that without serosa invasion (85. 7%). Conclusion: The multidrug resistance cells are present in primary gastric carcinomas prior to chemotherapy and analysis of mdr-l gene, MRP, LRP may have guiding significance in the treatment of gastric carcinoma.

Key concepts: Multiple drug resistance, Messenger RNA, Clinical significance, Flow cytometry, Gastric carcinoma, Gene, Cancer, Cancer research

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