Expression of lung resistance protein and Multidrug resistance-associated protein in Esophageal carcinoma

Objective To investigate the expression of lung resistance protein(LRP) and multidrug resistance-associated protein(MRP) in esophageal carcinoma.Methods The expressions of LRP protein and MRP protein were detected by immunohistochemical staining in 81 cases of esophageal carcinoma.Results The expression of LRP protein was significantly higher in cancer(54.3%) than that in normal tissues(35.9%,P0.05).The expression of LRP was incorrelate with carcinoma differentiation,invasive extent and lymph node metastasis in esophageal carcinoma.The expressions of MRP protein were obviously higher in carcinoma than that in normal tissues(P0.05).The expressions of MRP in deeper invasing group and group with lymph node metastasis were significantly higher than those in superficial invasing group and group without lymph node metastasis(P0.05).It was not observed that MRP protein expressions were related to carcinoma differentiation(P0.05).It was not found that the significant correlation between LRP and MRP protein(P0.05).Conclusion The overexpression of LRP in cancer tissues maybe correlate with drug resistance in esophageal carcinoma.High expression of MRP might inflect deeply infiltrating of the tumor and indicate metastasis of lymph node.There is no significant correlation in pathological characteristics between LRP protein and MRP protein.