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2009•Medical Journal of Chinese People's HealthRequires access

Sertraline plus clozapine in the treatment of obsessive -compulsive disorder

Ning Zhuang

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Abstract

Objective: To explore the efficacy of sertraline plus clozapine in the treatment of obsessive - compulsive disorder (OCD). Methods: A total of 55 patients with OCD who met the criteria of CCMD -3 were randomly treated rapeutic group(n = 30) and control group( n = 25 ) for the treatment of 8 weeks. The efficacy was measured with Yale - Brown obsessive - compulsive scale( Y-BOCS), Hamilton depression scale (HAMD) and Hamilton anxiety scale(HAMA). Results: After treatment there were significant differences between two groups in overall response showed by the reduction rate of Y - BOCS, HAMD and HAMA total scores. Conclusions: Sertraline plus clozapine have a superior effectiveness in the treatment of OCD.

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What this paper is about

Objective: To explore the efficacy of sertraline plus clozapine in the treatment of obsessive - compulsive disorder (OCD). Methods: A total of 55 patients with OCD who met the criteria of CCMD -3 were randomly treated rapeutic group(n = 30) and control group( n = 25 ) for the treatment of 8 weeks. The efficacy was measured with Yale - Brown obsessive - compulsive scale( Y-BOCS), Hamilton depression scale (HAMD) and Hamilton anxiety scale(HAMA). Results: After treatment there were significant differences between two groups in overall response showed by the reduction rate of Y - BOCS, HAMD and HAMA total scores. Conclusions: Sertraline plus clozapine have a superior effectiveness in the treatment of OCD.

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Available abstract

Objective: To explore the efficacy of sertraline plus clozapine in the treatment of obsessive - compulsive disorder (OCD). Methods: A total of 55 patients with OCD who met the criteria of CCMD -3 were randomly treated rapeutic group(n = 30) and control group( n = 25 ) for the treatment of 8 weeks. The efficacy was measured with Yale - Brown obsessive - compulsive scale( Y-BOCS), Hamilton depression scale (HAMD) and Hamilton anxiety scale(HAMA). Results: After treatment there were significant differences between two groups in overall response showed by the reduction rate of Y - BOCS, HAMD and HAMA total scores. Conclusions: Sertraline plus clozapine have a superior effectiveness in the treatment of OCD.

Key concepts: Hamd, Sertraline, Hamilton depression scale, Clozapine, Obsessive compulsive, Depression (economics), Psychology, Anxiety

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