Change of peripheral blood CD5~+B cells in hepatitis B patients and its association with indexes of liver function

Objectives:To explore the change of peripheral blood CD5 +B cells and its association with indexes of liver function in patients with hepatitis B. Methods:Change of peripheral blood CD5 +B cells was detected immunohistochemically. The indexes of liver function were examined by HITAI 7170 automatic analyzer. Results:There were no significant differences in the percentage of peripheral blood CD5 +B cells between patients with acute hepatitis B and normal controls. With the severity development of hepatitis B from chronic hepatitis to cirrhosis, the percentage of peripheral blood CD5 +B cells is positively correlated with the increase of ALT,AST,GGT,TB and ALB. Conclusions:A large number of CD5 +B cells are activated in patients with chronic hepatitis B, heavy chronic hepatitis or cirrhosis. The percentage of peripheral blood CD5 +B cells increases concomitantly with the liver impairment.