Relationship between the chemokine receptor CCR2b gene G190A polymorphism and cerebral infarction of Han population in Chinese Fujian district

Objective To investigate the relationship between chemokine receptor CCR2b gene G190A polymorphism and cerebral infarction(CI) of Han population in Chinese Fujian district.Methods The G190A polymorphism in ccr2b gene was detected by polymerase chain reaction-restriction fragment length polymorphism analysis(PCR-RFLP) and DNA sequencing in 200 patients with CI(CI group) and 200 normal controls(NC group).Results There were significant differences in frequencies of allele and genotype of CCR2b G190A gene polymorphism between CI and control groups(P0.05).In CI group,genotypic frequency of GG was 83.5%,GA was 15.0%,AA was 1.5%.The allele frequency of G was 91.0% and A was 9.0%.In NC group,genotypic frequency of GG was 73.0%,GA was 22.5%,AA was 4.5%.The allele frequency of G was 84.3% and A was 15.7%.The frequencies of CCR2b 190GG genetype and G allele in CI group were siginificantly higher than that in NC group(P0.05).Conclusions There was association between CCR2b gene G190A polymorphism and cerebral infarction(CI) in Chinese Fujian district Han populations.The CCR2b G190 allele may be a genetic risk factor for cerebral infarction of Han populations in Chinese Fujian district.