Association of 344-35C/T Polymorphism of Growth Arrest-Specific Gene 6 with Cerebral Infarction

Objective To investigate the correlations of the single nucleotide polymorphism(SNP) 344-35C/T of growth arrest-specific gene 6(GAS6) gene and cerebral infarction in Han population in the western Guangdong province.Methods The restriction fragment length polymorphism(PCR-RFLP) was used to determine the 344-35C/T polymorphism in the intron region of GAS6 gene in the case group(n= 180) and healthy control group(n=150).Results There was no significant association between GAS6-344-35C/T and cerebral infarction(P 0.05).After stratified by gender in chi-square test in women population,the frequency of C allele was significantly higher in cases(77.9%) than that in controls(66.4%)(P=0.040);The frequency of the CC genotype was significantly higher in cases(61.8%) than that in controls(43.1%)(P=0.036).Conclusion In Han women in western Guangdong province,C allele of GAS6-344-35C/T polymorphism is a risk fac-tor of cerebral infarction,CC genotype is a susceptible genotype of cerebral infarction.