Determination of residual organic solvents in zonisamide by capillary gas chromatography

Objective To develop a gas chromatography method for the determination of residual organic solvents in zonisamid.Methods The samples were injected into DB-624 capillary column and analyzed with FID detector using n-propyl alcohol as the internal standard.Results The linear ranges of methanol,ethanol,ethyl acetate,acetic acid were 15.029-240.464 mg·L-1(r=0.999 9),24.964-399.424 mg·L-1(r=1),25.02-400.32 mg·L-1(r=0.999 9),24.99-399.84 mg·L-1(r=0.999 9),respectively.The recoveries were 99.5%,99.0%,98.9%,99.2%;RSD were 1.2%,1.4%,1.2%,1.5%(n=9),respectively.Conclusions The method is simple,accurate and sensitive with good reproducibility.It can be used for the determination of the residual organic solvents in zonisamide.