Relationship between Streptozotoci Induced Impaired Glucose Tolerance and Its Dosage in the Neonatal Rats

Objective To explore the relationship between streptozotocin (STZ) induced impaired glucose tolerance (IGT) and its dosage in the neonatal rats.Methods Thirty-two neonatal Wistar rats were randomly and evenly divided into four groups.The control group was injected ip with 0.1 mmol/L citric acid-citrate sodium buffer solution.Another three groups were injected ip with 60 mg/kg,80 mg/kg and 100 mg/kg STZ.The fasting and postprandial plasma glucose (PG) levels were detected after 10 weeks and rechecked after 15 weeks.Results After 10 weeks,the fasting PG level was significantly higher in the 100 mg/kg STZ group (P0.05),and the postprandial PG level was significantly higher in 80 mg/kg and 100 mg/kg STZ groups (P0.05) than the control group.After 15 weeks,the fasting PG levels were not significantly different (P0.05),and the postprandial PG levels were higher in 80 mg/kg and 100 mg/kg STZ groups (P0.05) compared with the control group.Conclusion The neonatal Wistar rats injected with 80 mg/kg STZ after ten weeks have the IGT characteristics and a stable IGT animal model can be established.