[Establishment of rat model of type 2 diabetes complicated with hypertension].

OBJECTIVE: To establish type 2 diabetic model in rats complicated with hypertension. METHODS: =13).Except that rats in the normal control group were fed with ordinary diet, rats in the other groups were fed with high-fat diet for 4 weeks, then maintained with free access to rat chow and 1% NaCl drinking water for 9 weeks. In addition, rats in streptozotocin(STZ) groups were received STZ at a different dose(20 mg/kg, 30 mg/kg, 40 mg/kg)respectively by intraperitoneal injection at the end of the fourth week. The experimental period lasted 13 weeks. During the study, the general condition, body weight, average food intake, blood glucose, blood pressure, blood lipids and plasma insulin levels of each rat were tested. RESULTS: week of the experimental period, each of which was only in 30 mg/kg STZ-1% NaCl-treated rats and 40 mg/kg STZ-1% NaCl-treated rats as compared with non-treated rats or 1% NaCl water-treated rats. CONCLUSIONS: The method that the rat was fed with high-fat diet for 4 weeks, then, received intraperitoneal injection of 30~40 mg/kg STZ combined with feeding 1% NaCl drinking water, which can induce insulin resistance in rats with type 2 diabetes mellitus and hypertension.