2011•The Chinese Journal of Clinical PharmacologyRequires access

Effect of Compound Jiangzhi Decoction on blood lipid in experimental hyperlipidemia rats

XU Guo-sheng

Abstract

Objective To observe influences of the modified Compound Jiangzhi Decoction on blood lipid in experimental hyperlipidemia rats.Methods Rats were given high fat diet for 4 weeks,resulting in model of hyperlipidemia,meanwhile the modified Compound Jiangzhi Decoction was given in three doses 1.07,2.14,4.28 g·kg-1 for 4 weeks.During the drug administration,body weight,and the levels of TG,CHO,LDLC,HDLC were measured.Results Compared with the model group,Compound Jiangzhi Decoction high dose group could reduce the contents of TG,CHO,LDLC in rat serum obviously(P0.01).It could improve state,body weight and the hemorrheologic exception by hyperlipidemia in rats.Conclusion The Compound Jiangzhi Decoction shows clear improvement for hyperlipidemia-related indicators.

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Key concepts: Decoction, Hyperlipidemia, Body weight, Blood lipids, Pharmacology, Chemistry, Cholesterol, Medicine