Experessions of VEGF-C and NF-_κB in breast cancer

Objective To investigate the role of vascular endothelial growth factor-C(VEGF-C) and nuclear factor kappa B(NF-κB) in the development and progression of breast cancer.MethodsThe expressions of VEGF-C and NF-κB were detected by immunohistochemistry assay in 59 cases of breast cancer,17 cases of breast intraductal carcinoma and 20 cases of tumor-adjacent normal tissues.The relationship between the expressions of VEGF-C and NF-κB and the clinicopathological features and survival rate was analyzed.Results The positive expression rates of VEGF-C and NF-κB were significantly different among breast cancer,breast intraductal carcinoma and tumor-adjacent normal tissues(71.2%,47.1%,0 and 62.7%,41.2%,10.0%,respectively)(P0.01).There was a positive correlation between VEGF-C and NF-κB(r=0.283,P0.05).The positive expression rate of VEGF-C was closely related with lymph node metastasis and TNM stage(P0.05),while NF-κB was related with histology stage and lymph node metastasis(P0.05).Moreover,the 5-year survival rate in patients with positive expressions of VEGF-C and NF-κB was lower than that in patients with negative expressions.Conclusion The positive expressions of VEGF-C and NF-κB are closely correlated with lymph node metastasis and may be the potential makers for predicting the prognosis of patients with breast cancer.