Expression and implication of Ki67 and P53 protein in laryngeal carcinoma

Objective To study the expression of Ki67 and P53 protein in laryngeal carcinoma and their relationship with the pathogenesis,development and prognosis.Methods Immunohistochemistry was used to study tissues of 141 cases with laryngeal carcinoma,18 cases with precarcinoma,15 cases with vocal cord polyps and 8 normal tissues adjacent to laryngeal carcinoma.Results A high level of Ki67 and P53 expression was found in laryngeal carcinoma than in non-carcinoma laryngeal lesions and normal tissues(P﹤0.01).The expression rate of Ki67 and P53 protein were stronger in 3rd and 4th stage laryngeal carcinoma than those of the first and second stages.Laryngeal carcinoma with cervical metastasis had higher expression than those without cervical metastasis.The 3 years and 5 years survival rate of Ki67 and P53 positive cases was lower than that of Ki67 and P53 negative cases(P﹤0.01 or 0.05).The overall positive rate was higher in carcinoma than in non-carcinomal laryngeal lesions and normal tissues(P﹤0.01).Conclusions The high expression of Ki67 and P53 protein maybe closely related to the pathogenesis,development and prognosis of laryngeal carcinoma.