Clinical observation of CO_2 laser combined with ALA photodynamic therapy for recurrent perianal Condyloma Acuminatum

AIM:To investigate the efficacy of CO2 laser combined with ALA photodynamic therapy for recurrent perianal Condyloma Acuminatum.METHODS:Forty-six patients with perianal Condyloma Acuminatum were randomly divided into two groups,experimental group for the CO2 laser combined with ALA photodynamic therapy(ALA-PDT),first with CO2 laser dispel wart body,exposing out photodynamic laser treatment,once a week for three consecutive times;control group for the CO2laser treatment group,visually the wart was completely cleared.One week after the treatment for efficacy evaluation,all patients were followed up to evaluate the recurrence rate within 3months after treatment.RESULTS:After treatment,the warts were completely disappear,the recurrence rate of experimental group and control group was 19%,65%,respectively.CONCLUSION:CO2 laser combined with ALA photodynamic therapy for recurrent perianal Condyloma Acuminatum is safely and effectively,can reduce the relapse rate.