Topical 5-Aminolevulinic Acid Photodynamic Therapy for Perianal Condyloma Acuminatum

Objective To evaluate the efficacy of topical 5-aminolevulinic acid photodynamic therapy for perianal condyloma acuminatum.Methods Totally 234 patients with perianal condyloma acuminatum were randomly assigned to the electrosurgical generator group,photodynamic therapy group,or electrosurgical generator-photodynamic therapy group.The treatment was repeated weekly for 3 times.The primary efficacy endpoint was the warts clearance rate 1 week after the last treatment.The recurrence rate was evaluated for continuous 3 months.ResultsThe warts were all disappeared after treatment by three methods,respectively.The mucous membranes were all normal.The recurrence rate of the 78 patients solely treated by electrosurgical generator was 55.1% and their average recurrence intervals were 24.6 days.The recurrence rate of ALA-PDT was 11.5% and their average recurrence intervals were 56.8 days.The recurrence rate of electrosurgical generator combined with ALA-photodynamic therapy was 8.97% and their average recurrence intervals were 80.1 days.ConclusionsThe results confirm that topical 5-aminolevulinic acid photodynamic therapy is a very effective method for the treatment of perianal condyloma acuminatum,especially combined with electrosurgical generator.It can reduce the recurrence risk and prolong the recurrent time.It can improve patients' qualities and cut off/decrease the sources of infection.