2011•Zhongguo shiyan fangjixue zazhiRequires access

Influence of Compound Liuyueqing on Proliferation and Extracellular Matrix of Hepatic Stellate Cells

Renbin Huang

Abstract

Objective:To study the influence of CLYQ on proliferation and extracellular matrix(ECM) of hepatic stellate cells(HSC).Method: Cytotoxicity caused by CLYQ was detected by MTT assay.The contents of hydroxyproline(Hyp),hyaluronic acid(HA) and tissue inhibitor of metalloproteinase-1(TIMP-1) in HSC cell supernate were detected by enzyme linked immunoabsorbent assay(ELISA).Result:TC50 is 6.191 g.L-1,and TC0 is 3.504 g.L-1.CLYQ could inhibit the proliferation of HSC.The various concentration group of CLYQ could degrade significantly the contents of Hyp,HA and TIMP-1 in cell supernate(P 0.05,P 0.01),presenting the dose-effect relationship.Conclusion:CLYQ can inhibit the proliferation of HSC,so that reducing the synthesis of ECM and hepatic fibrosis.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Hepatic stellate cell, Hydroxyproline, Extracellular matrix, Hyaluronic acid, Hepatic fibrosis, Cell growth, Chemistry, Matrix metalloproteinase