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2004•Chinese Journal of Clinical HepatologyRequires access

Effect of Curcumin on proliferation and extracellular matrix secretion of rat hepatic stellate cells in vitro

Li Li

Open publisher page 1 citations

Abstract

To investigate the effects of Curcumin on proliferation and extracellular matrix secretion of rat hepatic stellate cells in vitro. HSC-T6 were incubated with different concentration of Curcumin for 24 hours. MTT colorimetry was used for assaying proliferation of HSC. Type Ⅰ collage was determined by ELISA. Hyaluronic acid and Laminin were measured by radioimmunoassay. addition of (1～20)μmol/L curcumin into culture medium had no cytotoxicity to HSC, but could significantly inhibi HSC proliferation, and also inhibit Type Ⅰ collage, hyaluronic acid and laminin secretion in different degree. Curcumin can significantly inhibi HSC proliferation and extracellular matrix secretion.

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What this paper is about

To investigate the effects of Curcumin on proliferation and extracellular matrix secretion of rat hepatic stellate cells in vitro. HSC-T6 were incubated with different concentration of Curcumin for 24 hours. MTT colorimetry was used for assaying proliferation of HSC. Type Ⅰ collage was determined by ELISA. Hyaluronic acid and Laminin were measured by radioimmunoassay. addition of (1～20)μmol/L curcumin into culture medium had no cytotoxicity to HSC, but could significantly inhibi HSC proliferation, and also inhibit Type Ⅰ collage, hyaluronic acid and laminin secretion in different degree. Curcumin can significantly inhibi HSC proliferation and extracellular matrix secretion.

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Available abstract

To investigate the effects of Curcumin on proliferation and extracellular matrix secretion of rat hepatic stellate cells in vitro. HSC-T6 were incubated with different concentration of Curcumin for 24 hours. MTT colorimetry was used for assaying proliferation of HSC. Type Ⅰ collage was determined by ELISA. Hyaluronic acid and Laminin were measured by radioimmunoassay. addition of (1～20)μmol/L curcumin into culture medium had no cytotoxicity to HSC, but could significantly inhibi HSC proliferation, and also inhibit Type Ⅰ collage, hyaluronic acid and laminin secretion in different degree. Curcumin can significantly inhibi HSC proliferation and extracellular matrix secretion.

Key concepts: Curcumin, Laminin, Hyaluronic acid, Extracellular matrix, Hepatic stellate cell, Secretion, Chemistry, In vitro

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