Drug resistance analysis of 337 smear-positive tuberculosis patients

Objective To analyze the drug resistance of the initial treatment and retreatment pulmonary TB patients registered in Handan,provide the reference for clinical and control of tuberculosis. Methods Culture positive and identify strain for the sputums of 337 smear-positive tuberculosis patients registered in Handan during 2013,test the resistance of mycobacterium tuberculosis for anti-isoniazid( H),rifampicin( R),streptomycin( S) and ethambutol( E) with proportion methods,and analyze the drug resistance of mycobacterium tuberculosis. Results The total resistance rate was 30. 56%,the MDR rate was 14. 84% in 337 smear-positive tuberculosis patients infected with mycobacterium tuberculosis. The total resistance rate and the MDR rate in retreatment group was higher than that in initial treatment group( P 0. 01). The drug resistance frequency of 4 kinds of anti-tuberculosis was respectively H( 42. 73%), S( 35. 31%), R( 28. 49%),E( 21. 66%) in descending order. The resistance rate for 4 kinds of anti-TB drugs was lower in initial treatment group than that in retreatment group( P 0. 01). Conclusions The incidence rate of resistant mycobacterium tuberculosis in tuberculosis patients in Handan was high,effective measures need to be taken for detection and prevention of drug-resistant TB.