Analysis of drug-resistance situation on 2672 pulmonary tuberculosis inpatients

Objective To understand drug-resistance situation of pulmonary tuberculosis inpatients.Methods According to TB diagnostic bacteriology testing procedures,specimens of positive sputum culture TB inpatients were collected,treated and subjected to bacteria culture,isolation and identification in Anhui Provincial Chest Hospital from November 2011to May 2013. New LJ media was used for culture of Mycobacterium tuberculosis.Susceptibility tests were performed against isoniazid,rifampicin,ethambutol and streptomycin.Results Overall drug-resistance rate was 25.5%for 2 672TB inpatients.For initial treatment group and retreatment group,drug-resistance rate was 12.6%and 58.8%,respectively,with significant difference(P0.01).Multidrug-resistance rate for initial treatment group and retreatment group was 4.1% and 34.7%,respectively, with significant difference(P0.01).Rate of resistance to 1,2,3,4kinds of anti-TB drug for retreatment group was higher than that of initial treatment group(P0.01).Streptomycin had the highest resistance rate(8.6%)in initial treatment group; while rifampicin had the highest resistance rate in retreated group(50.5%).Different drugs against TB demonstrated significant difference for drug resistance rate in above 2groups(P0.01).Occurrence of irregular medication and treatment interruption accounted for 79.5%of drug-resistance cases in retreatment group.Conclusion Drug-resistance was a serious problem among TB patients.Irregular medication and treatment interruption were major reasons.Supervision and management should be strengthened to prevent generation and spreading of drug-resistance strains.