Correlation analysis between fasting serum connecting peptide level with Type 2 diabetic nephropathy

Objective To explore the correlation between fasting connecting peptide(FCP) level with Type 2 diabetic nephropathy (DN) morbility factor in the patients with diabetes mellitus(DM).Methods 258 patients with DM in our hospital during June of 2006 to December of 2008 were collected by retrospective analysis.187 patients were in the group of DM and 71 in DN group,respectively.Serum FCP,glomerular filtration rate(GFR),total cholesterol(TC),triglyceride(TG),renal function,glycosylated hemoglobin(HbA1c),urine microalbumin(mAlb) and body mass index(BMI) were detected respectively.FCP was compared with these experiment index.Results 1)Along with the FCP level descend,The stages of DN was hoist gradually(χ~2=43.7,P0.001);2)These levels of ages,BMI,TG and HDL-C were not difference between two groups,P0.05.These levels of course of disease,TC,LDL-C,HbA1c and mAlb in DN group were higher than it in DM group,but GFR and CP in DN group were lower than it in DM group,there were significantly difference,P0.01;3)The serum concentration of CP was negative correlation with course of disease(r=-0.317,P0.01),HDL-C(r=-0.201,P0.05) and mAlb(r=-0.285,P0.05).It was positive correlation with TG(r=0.275,P0.01) and GFR(r=0.507,P0.01),reapectively.But there not correlation with age,fasting blood glucose and HbA1c,P0.05.Conclusion There is intimate correlation between FCP level with the stages of DN.Remaining physiological FCP concentration in the patients with DM may delay its development of DN.