Analysis of the Influence of Metabolic Syndrome on Diabetic Nephropathy in Type 2 Diabetes

Objective To investigate the relationship between metabolic syndrome(MS) and diabetic nephropathy(DN) in type 2 diabetes mellitus(T2DM).Methods According to the diagnostic standard of CDS(2004),1 025 inpatients of T2DM were divided into three groups:single abnormal group(group 1),two abnormal group(group 2) and MS group(group 3),and DN prevalence was compared among three groups.The individuals were divided into two groups:DN group and non-DN group according to the albumin/creatinine ratio and the differences of the blood sugar,the blood pressure,the blood fats levels were compared between two groups.Multiple regression analysis was performed on the relation of DN with MS and its components.Results The prevalence of DN and MS in the present study was 39.0%,38.1%,respectively.In the group 1,group2 and group 3,the prevalence of DN was 17.9%,32.7%,56.3%,respectively.In the DN group,the parameters including HbA1C,systolic pressure(SBP),diastolic pressure(DBP),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),age,the diabetes course were obviously higher than those in the non-DN group(P0.05 or P0.01),while the level of high density lipoprotein cholesterol(HDL-C) was lower than that in the non-DN group(P0.05).Multiple regression analysis showed that,the diabetes course,SBP,TG,LDL-C and MS were independent risk factors for DN in T2DM.Conclusion MS is a factor related to DN in patients with T2DM.