Analysis of Blood Concentration Monitoring of Antiepileptic Drugs in 1 037 Patients

OBJECTIVE:To emphasize the drug monitoring and provide reference for safer and more reasonable use of antiepileptic drugs.METHODS:The information and blood concentration of epileptic patients receiving antiepileptic drugs therapy (carbamazepine,sodium valproate,phenobarbital) in our hospital were investigated retrospectively from Jan.2009-Jun.2012,and analyzed statistically by SPSS 20.0 software.RESULTS:1 037 epileptic patients who took 4 antiepileptic drugs were collected.The number of patients whose blood concentration were within therapeutic range,lower or higher ranges were 508 (48.99%),454 (43.78%),75 (7.23%),respectively;the proportion of patients whose blood concentration were within therapeutic range among 4 drugs was different (P0.007 1) except the sodium valproate and phenytoin (P=0.98).In addition,the blood concentration of carbamazepine and sodium valproate in underage was different from that in adults (P0.05).CONCLUSIONS:It is of significance for safe and effective use of antiepileptic drugs that emphasize concentration monitoring,especially for the aged and children.