Efficacy Observation of Fluoxetine Hydrochloride in the Treatment of Post-stroke Depression

OBJECTIVE: To observe the clinical efficacy of fluoxetine hydrochloride for post-stroke depression (PSD) patients and effect of it on neural function of PSD patients. METHODS: Diagnosed 64 PSD patients of our hospital were randomly divided into treatment group (n=32) and control group (n=32) according to drug use. Antidepressant or anti-anxiety agents discontinued before treatment. Treatment group took 1 tablet of fluoxetine hydrochloride in the morning, and control group were treated with amitriptyline 25 mg·d-1, tid. 2 groups received 12 weeks of treatment. Blood and urine routine, and liver and kidney functions were examined before and after treatment. RESULTS: After treatment of 12 weeks, Hamilton Depression Rating Scale (HAMD) and Neural Function Defect score (NIHSS) of 2 groups were significantly decreased, compared with before treatment (P0.05), and range of decrease in treatment group was more significant than control group (P0.05). The effective rate of treatment group (84.38%) was significantly higher than in control group (56.25%, P0.05). Obvious adverse drug reactions were not observed in 2 groups. CONCLUSIONS: Fluoxetine hydrochloride shows accurate curative effect on patients with PSD, can significantly improve the depressive mood and further improve the neurological function with low ADR.