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2009•Carcinogenesis,Teratogenesis and MutagenesisRequires access

Acute Toxicity and Genotoxicity of Bioactive Peptide Powders

Min Chen

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Abstract

BACKGROUND AND AIM: To study the safety of bioactive peptide powders.MATERIALS AND METHODS: Acute toxicity test of mice,Ames test,micronucleus test of bone marrow PCE cell in mice,sperm shape abnormality test of mice were used.RESULTS: Bioactive peptides revealed a LD5010 g/kg in mice.The results of genetic toxicity test were all negative,including Ames test,micronucleus test and sperm shape abnormality test.CONCLUSION: The bioactive peptide powders was a substance with no toxicity and no genotoxicity under our experimental conditions.

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BACKGROUND AND AIM: To study the safety of bioactive peptide powders.MATERIALS AND METHODS: Acute toxicity test of mice,Ames test,micronucleus test of bone marrow PCE cell in mice,sperm shape abnormality test of mice were used.RESULTS: Bioactive peptides revealed a LD5010 g/kg in mice.The results of genetic toxicity test were all negative,including Ames test,micronucleus test and sperm shape abnormality test.CONCLUSION: The bioactive peptide powders was a substance with no toxicity and no genotoxicity under our experimental conditions.

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Available abstract

BACKGROUND AND AIM: To study the safety of bioactive peptide powders.MATERIALS AND METHODS: Acute toxicity test of mice,Ames test,micronucleus test of bone marrow PCE cell in mice,sperm shape abnormality test of mice were used.RESULTS: Bioactive peptides revealed a LD5010 g/kg in mice.The results of genetic toxicity test were all negative,including Ames test,micronucleus test and sperm shape abnormality test.CONCLUSION: The bioactive peptide powders was a substance with no toxicity and no genotoxicity under our experimental conditions.

Key concepts: Genotoxicity, Ames test, Micronucleus test, Toxicity, Sperm, Micronucleus, Acute toxicity, Pharmacology

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