Randomized Controlled Clinical Study of Sparfloxacin Compared with Lomefloxacin

Sparfloxacin is a new fluroquinolones which has a long half-life time,perfect tissue penetration,broad spectrum.Sparfloxacin was evaluated the clinical efficacy and adverse reaction events,compared with lomefloxacin in randomized controlled study.Sparfl oxacin was administr ated for treating 45 patients with the respiratory infection,urinary infection,skin and soft tissue infection,and burn skin infection et al,in 200mg QD×5～10 days.The clinical cure rate and effective rate were 77 78% and 91 11%,those of lomefl oxacin were 67 44% and 86 65%( P 0 05).The bacteria eliminate rate and negative change's rate of sparfloxacin treat group were 92 50% and 92 30%,those of lomefloxacin were 86 85% and 86 49%( P 0 05).The susceptibility of the clinical bacteria to sparfloxacin and lomefloxacin were 93 59% and 91 03%( P 0 05).From the result,sparfloxacin is a convenient,safe and effective antimicrobial agents.