1999•The Chinese Journal of Clinical PharmacologyRequires access
RANDOMIZED CONTROLLED AND OPEN CLINICAL TRIAL ON SPARFLOXACIN COMPARED WITH LOMEFLOXACIN
Jia Li
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Abstract
A randomized controlled clinical trial on sparfloxacin compared with lomefloxacin was conducted. 59 patients with respiratory and urinary tsact infections were randomized to receive either sparfloxacin 200 mg po qd or lomefloxacin 200 mg po qd for 7～14 days. The clinical efficacy rates of sparfloxacin and lomefloxacin were 93.3% and 82.8% respectively. The bacterial clearance rates of the two drugs were 96.7% and 92.9% respectively. The adverse drug reactions of both groups were mild with the rates of 6.25% and 6.67% respectively. An open trial on sparfloxacin for 22 patients with skin and soft tissue infections was conducted. The clinical efficacy rate and the bacterial clearance rate were both 100%. The adverse drug reactions were mild with the rates of 13.64%.