Expression of PCNA and ER,PR in breast cancer

Objective To approch the correlation relationship between the expression of PCNA and ER,PR in breast cancer and evaluate the significance of combine detection in formulating endocrine therapeutic regimen after breast cancer operation.Methods The immunohistochemical expression of PCNA,ER and PR were examined in 80 patients with breast cancer.Results (1)Among 80 cases,the positive rate of ER,PR and PCNA were 65.0%,57.5%,63.75% respectively.(2)The positive rate of PCNA in group with lymphatic metastasis was significantly higher than that in group without lymphatic metastasis(P0.01) and there was positive relationship between lymphatic metastasis and positive expression of PCNA(P0.01).(3)The positive rate of PCNA in group without the expression of ER,PR was significantly higher than that in group with the expresson of ER,PR in breast cancer and there was negtive relationship between the expression of ER,PR in breast cancer and positive expression of PCNA(P0.01).Conclusion The positive rate of PCNA is related with the positive or negative expression of ER,PR in breast cancer.Associating PCNA with ER,PR detection can provide the ancillary evidence to predict the prognosis and to formulate the treatment plan of endocrinetherapy after breast cancer operation.