2007•Medical Journal of Chinese People's HealthRequires access

A controlled study on the treatment of senile depression with Citalopram and amitriptyline

Zhu Jia-sheng

Abstract

Objective:To explore the efficacy and side effects of Citalopram and amitriptyline.Methods:96 elderly depressive patients who met CCMD-3 criterion for depression episode were randomly assigned to Citalopram group(n=48) and amitriptyline group(n=48) for the treatment of 8 weeks.The clinical efficacy was evaluated by HAMD and HAMA.The side effects were evaluated by TESS.Results: There was no significant difference of the efficacy between two groups(P0.05).Citalopram showed rapider efficacy and less side effects than amitriptyline(P0.05).Conclusions: Citalopram showed observably rapider efficacy in reducing depression and anxiety symptoms and less side effects in treating elderly depression.

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Key concepts: Citalopram, Amitriptyline, Hamd, Depression (economics), Clinical efficacy, Medicine, Side effect (computer science), Anxiety