2006•Medical Journal of Chinese People's HealthRequires access
Comparative study of citalopram and amitriptyline in treatment of patients with senile depression
Dexing Liu
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Abstract
Objective:To appraise the efficacy and side effects of citalopram in treatment of senile depression.Methods:sixty senile patients with depression were treated with HAMD and TESS at the time of 1、2、、4、6weeks after treatment.Results: There was significant difference in the reduction of HAMD in both groups at first week.The reduction of HAMD was significant in both of these two groups at the time of 2、4、6 weeks after treatment.The incidence of cholinergic effect of citalopram was less than that of amitriptyline,but it took effects more quickly.Conclusions: citalopram possessed efficacy similar to that of amitriptyline.Citalopram is an effective antidepressant for senile depression,and its therapeutic effects is comparable with amitriptyline with less side effects.