Therapeutic Effect of Intravenous Injection with Cedilanid and Metoprolol Tartrate on Mitral Stenosis Complicating with Acute Pulmonary Edema and Atrial Fibrillation

Objective To observe the effect of intravenous injection with cedilanid and small does of metoprolol tartrate on mitral stenosis complicating with acute pulmonary edema and atrial fibrillation.Methods Sixty patients with mitral stenosis complicating with acute pulmonary edema and atrial fibrillation from January 2005to February 2010were randomly divided into cedilanid group and drug combination group,which was administered with cedilanid,or cedilanid and small does metoprolol tartrate by intravenous injection,respectively.Systolic blood pressure,heart rate,respiratory rate,pulse oxygen saturation(SpO2),dypnea,rales over lung field and the time from beginning of treatment to pulmonary edema improved were monitored as soon as the treatment began.Results There was no sig-nificant difference in basic data such as systolic blood pressure,heart rate,respiratory rate and SpO2at the beginning of treatment between the two groups,and no obvious difference was seen in systolic blood pressure at all the time of treatment between the two groups;while a obvious decrease took place in heart rate between cedilanid group and drug combination group after the treatment began;the time from beginning of treatment to pulmonary edema in drug combination group was much shorter than that in cedilanid group[(71.37±13.37),(78.77±14.74)minutes,P=0.046]. Conclusion Without contraindication of metoprolol,intravenous injection with cedilanid combined with small dose of metoprolol can effectively,quickly and safely treat the patients with mitral stenosis complicating with acute pulmonary edema and atrial fibrillation by controlling the heart rate.