The Efficacy of Intravenous Metoprolol on Heart Failure with Atrial Fibrillation of Rapid Ventricular Rates

Objective To observe the efficacy and safety of intravenous metoprolol combined with cedilanid(lanatoside C) in treatment of patients with heart failure of atrial fibrillation of rapid ventricular rates.Methods Patients with heart failure of atrial fibrillation of rapid ventricular rates were first administrated cedilanid and observed half an hour,if ventricular rate was still above 100 beats/min and blood pressure was above 100/60 mmHg,then the patients were given metoprolol 10mg by minipump in an hour.When either ventricular rate was≤60 beats/min or blood pressure90/60 mmHg,intravenous metoprolol was stopped.Before and after metoprolol treatment,the symptom and physical sign,heart rate,blood pressure,the rale,the blood rheology,BNP and ANP were examined.Results The heart rate decreased by 23.73 beats/min(P0.01),and SBP lowed by 5.69 mmHg(P0.05),DBP lowed by 5.26 mmHg(P0.05) after metoprolol treatment.There were significant changes in SI,SV,VI,SVRI and LVET(P0.05),however, BNP and ANP had no changes after metoprolol treatment.Conclusions Intravenous metoprolol combined with cedilanid is safe and effective in treating heart failure with atrial fibrillation.