Dynamic changes of serumal and gastric gastrin in patients with cerebral hemorrhage

Objective To explore the clinical significance of acute cerebral hemorrhage to the gastrointestinal dynamics. Method The rdioimmunological method was used to determine the dynamic gastrin (GAS) in 32 coma patients with acute cerebral hemorrhage. Results The levels of serumal and gastric GAS in cematose patients were significantly higher than those in the control for the first week after cerebral hemorrhage. During the first 24 h following the hemorrhage, the levels were only slightly higher than those in the control, but reached their peaks during the second 24 h and lasted for 1-3 d, and began to decline aterwards till the 4th week when they resumed normality. The lower the GCS of the patients was, the higher the levels of GAS in blood and gastric juice and the frequency of the patients' vomitting were and the grater gastric occult blood positive rate was, The contents of GAS in different hemorrhagic brain regions were compared with the LSD group, which showed no statistical significance, Conclusion There was abnormal GAS secretion in coma patients with acute cerebral hemorrhage. As an important (cerebroerapitide) hormone, and powerful media of neurotransmitter in central and peripheral nervous system. GAS plays an important part in the secondary physiological and pathological lesion to the brain after acute cerebral hemorrhage. Dynamic measurement and analysis of the levels of serums and gastric GAS are of great significance in judging the degree of acute cerebral hemorrhage and help understand the impact of cerebral hemorrhage on the gastromtestinal dynamics.