2008•Zhongguo yaofangRequires access
Effects of Danhong Injection on Plasma Levels of TNF-α and IL-6 and Its Clinical Efficacy in Patients with Acute Cerebral Infarction
WU Gong-zhu
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Abstract
OBJECTIVE:To observe the clinical efficacy of Danhong injection and its impact on plsma levels of TNF-α and IL-6 in patients with acute cerebral infarction.METHODS:80 patients with acute cerebral infarction were randomly divided into two groups: 40 in control group were treated with conventional therapy, while the other 40 in treatment group with conventional therapy in combination with Danhong injection.The changes of neurologic function score(NIHSS), clinical effect and the plasma levels of TNF-α and IL-6 after 2-week treatment were compared between the two groups. RESULTS: There were signficnant differences in neurologic impairment score(NIHSS), clinical effect and the plasma levels of TNF-α and IL-6 between the treatment group and the control group after treatment (P0.05). CONCLUSION: Danhong injection showed remarkable efficacy on acute cerebral infarction possibly by regulating plasma levels of TNF-α and IL-6, decreasing the expression of inflammatory cytokines and and improving cerebral blood flow.