Clinical observation on esculin and digitalisglycosides eye drops for dry eyes after LASIK

Objective To observe and evaluate the effect of esculin and digitalisglycosides eye drops for dry eye after LASIK.Methods Fifty-six post-LASIK patients (112 eyes) were recruited in the study,break-up time (BUT) were less than 5 seconds,contact lens were removed as least 2 weeks.Patients had complaints such as dry and sore eye,and were divided into experimental group (30 cases,60 eyes) and control group (26 cases,52 eyes),the patients in experiment group received the esculin and digitalisglycosides eye drops,and the control group received sodium hyaluronate eye drops.The postoperative BUT,subjective symptom scoring,corneal fluorescein staining scoring and corneal aberration in two groups were observed and compared.Results BUT at postoperative 1 day,1 week,2 weeks and 4 weeks were (2.52±0.98)seconds,(2.88±1.14)seconds,(3.03±1.49)seconds and (2.90±1.44)seconds in experimental group,respectively,which were (2.46±0.68)seconds,(2.74±0.82)seconds,(2.76±0.77)seconds and (2.67±0.80)seconds in control group,respectively,there was no statistical difference between different time points(P0.05),but a increasing trend was found in the two groups.The subjective symptom scoring at postoperative 1 day,1 week,2 weeks and 4 weeks were 3.82±1.91,3.50±2.30,3.13±2.33 and 2.60±2.45 in experimental group,respectively,which were 4.54±2.94,3.77±2.41,3.69±2.25 and 3.00±1.94 in control group,respectively,there were significant differences between different time points in two groups(Experiment group:P=0.024;Control group:P=0.016).There was no statistical difference in postoperative BUT,corneal fluorescein staining scoring and corneal aberration between two groups (all P0.05).Conclusion Esculin and digitalisglycosides eye drops is effective and safe for dry eye after LASIK.