Expression and Investigation of Survivin and VEGF in Benign and Malignant Gastric Ulcer

Objective: This study aimed to investigate the expression of Survivin and VEGF in benign gastric ulcer, malignant gastric ulcer, as well as the correlation between the expression in ulcerative gastric cancer and clinicopathological characteristics, and to analyze their roles in the development of gastric cancer and the relationship of expression in gastric cancer. Methods: S-P Immunohistochemical staining examinations were performed to detect different expressions of Survivin and VEGF in benign gastric ulcer, gastric ulcer with moderate to severe dysplasia and ulcerative gastric cancer. Combining with correlative clinicopathological characteristics, subsequent experimental data analysis was carried out. Results: Expression rates of Survivin and VEGF, which are significantly different(P0.01), are respectively 16.2 % and 24.3 % in benign gastric ulcers, 52.3 % and 45.5 % in gastric ulcer with moderate to severe dysplasia,71.4 % and 55.3 % in ulcerative gastric cancer. Different expressions of Survivin and VEGF are related to the depth of infiltration, lymphatic metastasis and TNM staging, In addition, the expression of Survivin has positive correlations with that of VEGF. Conclusions: Survivin in ulcerative gastric cancer is highly expressed, which are the key of gastric cancer progression and indicates poor prognosis. Survivin has potential application value in the diagnosis and prognosis of gastric cancer. It may be valuable to take dynamic expression monitoring of Survivin and VEGF in gastric ulcers, for Survivin and VEGF have synergistic action in the development and progression of ulcerative gastric cancer. Survivin and VEGF can be considered indices for invasion, metastasis and progression. Furthermore, combined detection of Survivin and VEGF may provide a new theoretical basis for comprehensive reatment of gastric cancer. Further research is expected to create a new era for the diagnosis and treatment of gastric cancer.