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2011•Unpublished venueRequires access

Determination of SYP-11277 by reversed phase HPLC

Dong Jingjing

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Abstract

A method was developed for the quantitative determination of SYP-11277 by reversed phase HPLC.[Methods] The sample was separated on a diamocil C18 column at the temperature of 30 °C with the elution of acetonitrile and water(80:20,by vol) as mobile phase at a flow rate of 1.0 mL/min.The detection wavelength was 254 nm.[Results] The assay exhibited a good linearity,the average recovery was 99.9%,and the standard deviation was 0.13.[Conclusions] The method has the advantages of convenience,fast speed,good separation,high precision and accuracy,and good linear correlations.

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What this paper is about

A method was developed for the quantitative determination of SYP-11277 by reversed phase HPLC.[Methods] The sample was separated on a diamocil C18 column at the temperature of 30 °C with the elution of acetonitrile and water(80:20,by vol) as mobile phase at a flow rate of 1.0 mL/min.The detection wavelength was 254 nm.[Results] The assay exhibited a good linearity,the average recovery was 99.9%,and the standard deviation was 0.13.[Conclusions] The method has the advantages of convenience,fast speed,good separation,high precision and accuracy,and good linear correlations.

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Available abstract

A method was developed for the quantitative determination of SYP-11277 by reversed phase HPLC.[Methods] The sample was separated on a diamocil C18 column at the temperature of 30 °C with the elution of acetonitrile and water(80:20,by vol) as mobile phase at a flow rate of 1.0 mL/min.The detection wavelength was 254 nm.[Results] The assay exhibited a good linearity,the average recovery was 99.9%,and the standard deviation was 0.13.[Conclusions] The method has the advantages of convenience,fast speed,good separation,high precision and accuracy,and good linear correlations.

Key concepts: Chromatography, Linearity, High-performance liquid chromatography, Acetonitrile, Chemistry, Relative standard deviation, Elution, Analytical Chemistry (journal)

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