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2006•He'nan nongye daxue xuebaoRequires access

Application of β-Cyclodextrin Derivatives as Mobile Phase Additives to Cellulose tris(3,5-dimethenylphenylcarbamate) Chiral Column

Chao Yuan

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Abstract

Cellulose tris(3,5-dimethylphenylcarbamate)(CDMPC) was synthesized.Elemental analysis and IR spectrum indicated that most of the hydroxy groups of the microcrystallin cellulose had been converted into ester groups.The silanized gel was coated with CDMPC by using tetrahydrofuran as solvent.The enantiomeric resolution of racemates on high performance liquid chromatography.When βcyclodextrin(β-CD),dimethyl β-cyclodextrin(DM-β-CD) and trimethyl βcyclodextrin(TM-β-CD) were used as mobile phase additives,Column CDMPC for separation of racemates possessed a new synergistic effect-two-phase synergistic effects.From the principle of supramolecular chemistry,we assume that the effect based on the supramolecular action of chiral stationary phase and chiral mobile phase additive.

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What this paper is about

Cellulose tris(3,5-dimethylphenylcarbamate)(CDMPC) was synthesized.Elemental analysis and IR spectrum indicated that most of the hydroxy groups of the microcrystallin cellulose had been converted into ester groups.The silanized gel was coated with CDMPC by using tetrahydrofuran as solvent.The enantiomeric resolution of racemates on high performance liquid chromatography.When βcyclodextrin(β-CD),dimethyl β-cyclodextrin(DM-β-CD) and trimethyl βcyclodextrin(TM-β-CD) were used as mobile phase additives,Column CDMPC for separation of racemates possessed a new synergistic effect-two-phase synergistic effects.From the principle of supramolecular chemistry,we assume that the effect based on the supramolecular action of chiral stationary phase and chiral mobile phase additive.

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Available abstract

Cellulose tris(3,5-dimethylphenylcarbamate)(CDMPC) was synthesized.Elemental analysis and IR spectrum indicated that most of the hydroxy groups of the microcrystallin cellulose had been converted into ester groups.The silanized gel was coated with CDMPC by using tetrahydrofuran as solvent.The enantiomeric resolution of racemates on high performance liquid chromatography.When βcyclodextrin(β-CD),dimethyl β-cyclodextrin(DM-β-CD) and trimethyl βcyclodextrin(TM-β-CD) were used as mobile phase additives,Column CDMPC for separation of racemates possessed a new synergistic effect-two-phase synergistic effects.From the principle of supramolecular chemistry,we assume that the effect based on the supramolecular action of chiral stationary phase and chiral mobile phase additive.

Key concepts: Cellulose, Cyclodextrin, Chemistry, Enantiomer, Tetrahydrofuran, Tris, Phase (matter), Supramolecular chemistry

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Application of β-Cyclodextrin Derivatives as Mobile Phase Additives to Cellulose tris(3,5-dimethenylphenylcarbamate) Chiral Column — Research Paper | ScholarLens