Preparation and application of cellulose tris(3,5-dimethylphenylcarbamate) chiral column

Cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC) were synthesized by the reaction of micrystalline cellulose with 3,5-dimethylphenylisocyanate in dry pyridine at 110℃. Elemental analysis and IR spectra indicated that most of the hydroxy groups of the microcrystalline cellulose had been converted into ester (groups. The) chiral stationary phases(CSP) were prepared by coating cellulose tris (3,5-dimethylphenylcarbamate) on the aminopyopyl silica. The evaluation of column was achieved hexane/2-propanol (90∶10 volume ratio) as mobile phase at a flow rate of 1mL·min~(-1) (at 25℃). And the results of the separation of chiral compound showed that the chiral stationary has good steroelectivity.